The Global Preclinical Antibacterial Pipeline

One of the drivers of antibiotic resistance is the lack of new antibiotics in the pipeline. The large pharmaceutical companies are now concentrating on drugs for non communicable diseases which are more profitable. This review has attempted to bring forward most complete and up to date information on current preclinical…

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A VersaTile-driven platform for rapid hit-to-lead development of engineered lysins
Acinetobacter baumannii bacteria, coloured scanning electron micrograph (SEM). This bacterium has developed resistance to a number of antibiotics and is increasingly seen in opportunistic infections in hospitals. It typically infects the lungs, leading to a form of pneumonia. It can develop resistance to antibiotics even as they are being used to treat an infection. Because of this, and because it is generally found in weakened patients, the mortality rate for infections with A. baumannii is high. In healthy individuals, however, it is a normal part of the skin flora. Magnification: x11,000 when printed 10 centimetres wide.

A VersaTile-driven platform for rapid hit-to-lead development of engineered lysins

The rapid emergence and spread of multi drug-resistant (MDR) bacteria is a major public health threat. This problem is further aggravated by the dearth of novel antibiotics. Out of the various antibiotics undergoing clinical trials only few reach the final phase above that the tendency of bacteria now to overcome…

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