The Importance of Antimicrobial Resistance in Medical Mycology

Prior to the SARS-CoV-2 pandemic, antibiotic resistance was identified as a major global health care concern. Although fungal infections remain largely unknown to the general public, total attributable annual deaths are comparable to or exceed global mortalities from malaria, tuberculosis, or HIV. The impact of fungal infections has been exacerbated…

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Safer Plant-Based Nanoparticles for Combating Antibiotic Resistance In Bacteria: A Comprehensive Review On Its Potential Applications, Recent Advances, And Future Perspective

The increasing issue of antibiotic resistance is a great challenge to the pharmaceutical industry. The pressure of developing newer, better compounds with capacity to kill or inhibit the growth of antibiotic resistant organisms is huge. In this direction, nanoparticles are gaining a lot of attention. For instance, the use of…

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Prevalence and Antimicrobial Resistance of Escherichia Coli in Chicken Meat and Edible Poultry Organs Collected from Retail Shops and Supermarkets of North Western Province in Sri Lanka

Escherichia coli (E. coli) is a bacterium that inhabits and colonize the guts of human beings and animals. Particular strains of this bacterium called ‘Shiga toxin-producing strains of E. coli’ (STECs) cause infections in humans due to the intake of food which is not cooked, partially cooked or contaminated with…

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Analysis of the Occurrence of Antibiotic Resistant Bacteria in the Hospital’s Effluent and its Receiving Environment

The use of antibiotics on a regular and excessive basis is a major factor in the spread of antibiotic-resistant bacteria. Patients discharge un-metabolized or relatively low doses of non-metabolized antibiotics through urine and stool, which might enter into the environment through sewage disposal and promote the emergence of antibiotic resistant…

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Time to Evaluate Decision Support Systems for Antimicrobial Prescribing Outside the Hospital

Computerised physician-order entry (CPOE) is a system where medical professional enter and send the treatment instructions and medications electronically instead of using paper chart method. computerised decision-support system (CDSS) is an application that helps healthcare providers in making therapeutic decisions, implement evidence- based clinical guidelines at the point- of- care.…

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Global Action on Antimicrobial Resistance: Lessons from the History of Climate Change And Tobacco Control Policy

Antimicrobial resistance is a public health threat that demands urgent action. AMR leads to reduced effectiveness of drugs like antibiotics resulting in milder and easily treatable infections turning to life-threatening conditions. AMR is increasing due to irrational use of antibiotics and hospital acquired secondary infections. In a recent commentary, experts…

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Antidepressants Promote the Spread of Extracellular Antibiotic Resistance Genes via Transformation

The unavoidable development of antibiotic resistance as a result of the use of antimicrobials is a major concern for human health. It is widely acknowledged that non-lethal antibiotic concentrations have accelerated the development and HGT process of antibiotic resistance. Compared to antibiotics, commonly prescribed non-antibiotic medications like antidepressants are also…

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Potentiating Hypoxic Microenvironment for Antibiotic Activation by Photodynamic Therapy to Combat Bacterial Biofilm Infections

Biofilm is complex self-secreted matrix of bacteria composing polysaccharides, extracellular DNAs, and proteins that have adhered to surfaces, to create a biofilm. Biofilms enable the infection to persist, prevent the absorption of antimicrobials, and encourage drug resistance in bacteria, making it challenging to treat bacterial infections. The bacteria are immune…

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Natural Products And Their Semi-synthetic Derivatives Against Antimicrobial-resistant Human Pathogenic Bacteria and Fungi

Antibiotic resistance (ABR) is a global priority, like climate change. The issue of ABR in India is quadrupled due to injudicious antibiotic use in the human, animal and plant sectors, poor knowledge, underutilisation of diagnostic procedures, inadequate health facilities, overpopulation, and poverty. It is pertinent to address this issue because…

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Low-Cost Anti-Mycobacterial Drug Discovery Using Engineered E. Coli

In the synthetic biology era, chemical genetics provides new tools for long-standing challenges in antimicrobial drug discovery. Microbial strains can be sensitised to drugs with specific mechanisms by making genetic changes to targeted functional pathways. High-throughput screening of these strains may then reveal new drugs that target the modified pathway…

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