Antibiotic Combinations Reduce Staphylococcus Aureus Clearance

The spread of antibiotic resistance has increased interest in combination-based treatments. Despite extensive research into the effects of drug combinations on bacterial growth, Much less is known about their effects on bacterial long-term clearance, particularly at cidal, clinically relevant concentrations. The authors systematically quantify Staphylococcus aureus survival during prolonged exposure…

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The Importance of Antimicrobial Resistance in Medical Mycology

Prior to the SARS-CoV-2 pandemic, antibiotic resistance was identified as a major global health care concern. Although fungal infections remain largely unknown to the general public, total attributable annual deaths are comparable to or exceed global mortalities from malaria, tuberculosis, or HIV. The impact of fungal infections has been exacerbated…

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Prevalence and Antimicrobial Resistance of Escherichia Coli in Chicken Meat and Edible Poultry Organs Collected from Retail Shops and Supermarkets of North Western Province in Sri Lanka

Escherichia coli (E. coli) is a bacterium that inhabits and colonize the guts of human beings and animals. Particular strains of this bacterium called ‘Shiga toxin-producing strains of E. coli’ (STECs) cause infections in humans due to the intake of food which is not cooked, partially cooked or contaminated with…

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Analysis of the Occurrence of Antibiotic Resistant Bacteria in the Hospital’s Effluent and its Receiving Environment

The use of antibiotics on a regular and excessive basis is a major factor in the spread of antibiotic-resistant bacteria. Patients discharge un-metabolized or relatively low doses of non-metabolized antibiotics through urine and stool, which might enter into the environment through sewage disposal and promote the emergence of antibiotic resistant…

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Time to Evaluate Decision Support Systems for Antimicrobial Prescribing Outside the Hospital

Computerised physician-order entry (CPOE) is a system where medical professional enter and send the treatment instructions and medications electronically instead of using paper chart method. computerised decision-support system (CDSS) is an application that helps healthcare providers in making therapeutic decisions, implement evidence- based clinical guidelines at the point- of- care.…

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Antidepressants Promote the Spread of Extracellular Antibiotic Resistance Genes via Transformation

The unavoidable development of antibiotic resistance as a result of the use of antimicrobials is a major concern for human health. It is widely acknowledged that non-lethal antibiotic concentrations have accelerated the development and HGT process of antibiotic resistance. Compared to antibiotics, commonly prescribed non-antibiotic medications like antidepressants are also…

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Potentiating Hypoxic Microenvironment for Antibiotic Activation by Photodynamic Therapy to Combat Bacterial Biofilm Infections

Biofilm is complex self-secreted matrix of bacteria composing polysaccharides, extracellular DNAs, and proteins that have adhered to surfaces, to create a biofilm. Biofilms enable the infection to persist, prevent the absorption of antimicrobials, and encourage drug resistance in bacteria, making it challenging to treat bacterial infections. The bacteria are immune…

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Natural Products And Their Semi-synthetic Derivatives Against Antimicrobial-resistant Human Pathogenic Bacteria and Fungi

Antibiotic resistance (ABR) is a global priority, like climate change. The issue of ABR in India is quadrupled due to injudicious antibiotic use in the human, animal and plant sectors, poor knowledge, underutilisation of diagnostic procedures, inadequate health facilities, overpopulation, and poverty. It is pertinent to address this issue because…

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Low-Cost Anti-Mycobacterial Drug Discovery Using Engineered E. Coli

In the synthetic biology era, chemical genetics provides new tools for long-standing challenges in antimicrobial drug discovery. Microbial strains can be sensitised to drugs with specific mechanisms by making genetic changes to targeted functional pathways. High-throughput screening of these strains may then reveal new drugs that target the modified pathway…

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Understanding Antimicrobial Use in Subsistence Farmers in Chikwawa District Malawi, Implications for Public Awareness Campaigns

Countries around the world have reported an increase in drug-resistant diseases over the past 20 years. This ramification is hampering human development and food security. The concept of climate change and antimicrobial resistance (AMR) is called "wicked policy challenges" by academics and policy actors because they arise from complex social…

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