A Synthetic Lipopeptide Targeting Top-Priority Multidrug-Resistant Gram-Negative Pathogens

Antimicrobial resistance is a major global health issue that requires immediate attention. Notably, multidrug-resistant (MDR) Pseudomonas aeruginosa, Acinetobacter baumannii, and Enterobacterales (e.g., Klebsiella pneumoniae) are major causes of morbidity and mortality. The World Health Organization (WHO) has identified these pathogens' carbapenem-resistant isolates as the top three priority pathogens for antibiotic…

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Two New Drugs to Fight Superbugs Available on NHS Soon

Antimicrobial resistance is a major issue which threatens to set modern medicine back to the pre-antibiotic era. Researchers estimate hard-to-treat infections already kill more than a million people per year globally. In this context world-leading innovations from United Kingdom are helping to develop two antibiotics which will save many lives. These…

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Implementing an Intervention to Reduce Use of Antibiotics for Suspected Urinary Tract Infection in Nursing Homes – A Qualitative Study of Barriers and Enablers Based on Normalization Process Theory

It is an established fact that any antibiotic use contributes to the development of antibiotic resistance. In elderly care homes, urinary tract infections (UTI) are common. To treat these infections, antibiotics are used, with most prescriptions being inappropriate. There are many factors that influence the prescription practices of the doctor.…

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Enhancing Pharmacists’ Role in Developing Countries to Overcome the Challenge of Antimicrobial Resistance: A Narrative Review

Antimicrobial resistance (AMR) is a global health challenge and developing countries are more vulnerable to the adverse health impacts of AMR. Health care workers including pharmacists can play a key role to support the appropriate use of antimicrobials in developing countries and reduce AMR. Success stories of pharmacist-led programs in…

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Isolation and Characterization of Multidrug Resistance Bacteria from Hospital Sewage Samples, Maharashtra, India

Antibiotics are known as life saver drugs that can act against bacteria. However the increasing problem of antibiotic resistance (ABR) has raised an alarm and has even attracted the attention of the World Health Organization (WHO). As per the guidelines from WHO, many countries including India framed the National Action…

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New Antibiotics for Multidrug-Resistant Bacterial Strains: Latest Research Developments and Future Perspectives

Antibiotics are crown to the modern medicine, and they are the weapon against numerous infectious diseases. The exposure of bacteria to ‘non-lethal levels’ of antibiotics is causing antibiotic resistance (ABR) in them. Multidrug resistance (MDR) is the most common type of resistance. The MDR refers to bacteria showing resistance to…

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Governing Antimicrobial Resistance: A Narrative Review of Global Governance Mechanisms

Antimicrobial resistance (AMR), a central health challenge of the twenty first century, poses substantial population health risks, with deaths currently estimated to be around 700,000 per year globally. After implementing effective policy responses to AMR, with a Global Action Plan on AMR approved by the World Health Assembly in 2015.…

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Antimicrobial resistance and Population Genomics of Multidrug-resistant Escherichia coli in Pig Farms in Mainland China

One of the most serious challenges to global public health is antimicrobial resistance (AMR). The advent and rapid spread of extensively drug-resistant (XDR), pandrug-resistant (PDR) bacteria and multidrug-resistant (MDR) particularly microorganisms resistant to last-resort antibiotics such as carbapenems, colistin, and tigecycline, has sparked widespread concern. Several drug-resistant bacteria are a…

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Discovery of Actinomycin L, A New Member of the Actinomycin Family of Antibiotics

Antibiotic resistance is the major emerging crisis that escalates among the pathogen. Hence newer, less toxic and efficient drugs remains the top priority. The majority source of antibiotics in use today is from Actinobacteria and the antibiotic identified is Actinomycin. Streptomyces’s is the crucial bioactive natural product producer that includes…

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Global Burden of Bacterial Antimicrobial Resistance in 2019: A Systematic Analysis

Antimicrobial resistance (AMR) is a global health issue. The irrational use of antibiotics in human, animal and environment sectors give rise to AMR. Apprehensions are rife that AMR may follow similar patterns as seen in case of epidemic outbreaks developing into pandemics. In this situation, it becomes imperative to understand…

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