Global Biogeography and Projection Of Soil Antibiotic Resistance Genes

It is a known fact that antibiotic resistance (ABR) is a multisectoral problem and to tackle it the approach also should be in multi directions which can be called a ‘one health’ approach. A systematic analysis has estimated that in 2019 globally around 4.95 million people lost their lives because…

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Antibiotic Combinations Reduce Staphylococcus Aureus Clearance

The spread of antibiotic resistance has increased interest in combination-based treatments. Despite extensive research into the effects of drug combinations on bacterial growth, Much less is known about their effects on bacterial long-term clearance, particularly at cidal, clinically relevant concentrations. The authors systematically quantify Staphylococcus aureus survival during prolonged exposure…

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Public Knowledge, Practices, and Awareness of Antibiotics and Antibiotic Resistance in Myanmar: The First National Mobile Phone Panel Survey

Antimicrobial resistance is a global public health challenge. In 2015, World Health Organization urged all its member states to develop respective national action plans to curb this crisis. In response to this, the Ministry of Health and Sports, Myanmar, published the National Action Plan for Containment of AMR in Myanmar…

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The Importance of Antimicrobial Resistance in Medical Mycology

Prior to the SARS-CoV-2 pandemic, antibiotic resistance was identified as a major global health care concern. Although fungal infections remain largely unknown to the general public, total attributable annual deaths are comparable to or exceed global mortalities from malaria, tuberculosis, or HIV. The impact of fungal infections has been exacerbated…

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Prevalence and Antimicrobial Resistance of Escherichia Coli in Chicken Meat and Edible Poultry Organs Collected from Retail Shops and Supermarkets of North Western Province in Sri Lanka

Escherichia coli (E. coli) is a bacterium that inhabits and colonize the guts of human beings and animals. Particular strains of this bacterium called ‘Shiga toxin-producing strains of E. coli’ (STECs) cause infections in humans due to the intake of food which is not cooked, partially cooked or contaminated with…

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Analysis of the Occurrence of Antibiotic Resistant Bacteria in the Hospital’s Effluent and its Receiving Environment

The use of antibiotics on a regular and excessive basis is a major factor in the spread of antibiotic-resistant bacteria. Patients discharge un-metabolized or relatively low doses of non-metabolized antibiotics through urine and stool, which might enter into the environment through sewage disposal and promote the emergence of antibiotic resistant…

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Antidepressants Promote the Spread of Extracellular Antibiotic Resistance Genes via Transformation

The unavoidable development of antibiotic resistance as a result of the use of antimicrobials is a major concern for human health. It is widely acknowledged that non-lethal antibiotic concentrations have accelerated the development and HGT process of antibiotic resistance. Compared to antibiotics, commonly prescribed non-antibiotic medications like antidepressants are also…

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Potentiating Hypoxic Microenvironment for Antibiotic Activation by Photodynamic Therapy to Combat Bacterial Biofilm Infections

Biofilm is complex self-secreted matrix of bacteria composing polysaccharides, extracellular DNAs, and proteins that have adhered to surfaces, to create a biofilm. Biofilms enable the infection to persist, prevent the absorption of antimicrobials, and encourage drug resistance in bacteria, making it challenging to treat bacterial infections. The bacteria are immune…

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Natural Products And Their Semi-synthetic Derivatives Against Antimicrobial-resistant Human Pathogenic Bacteria and Fungi

Antibiotic resistance (ABR) is a global priority, like climate change. The issue of ABR in India is quadrupled due to injudicious antibiotic use in the human, animal and plant sectors, poor knowledge, underutilisation of diagnostic procedures, inadequate health facilities, overpopulation, and poverty. It is pertinent to address this issue because…

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Low-Cost Anti-Mycobacterial Drug Discovery Using Engineered E. Coli

In the synthetic biology era, chemical genetics provides new tools for long-standing challenges in antimicrobial drug discovery. Microbial strains can be sensitised to drugs with specific mechanisms by making genetic changes to targeted functional pathways. High-throughput screening of these strains may then reveal new drugs that target the modified pathway…

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