A Synthetic Lipopeptide Targeting Top-Priority Multidrug-Resistant Gram-Negative Pathogens

Antimicrobial resistance is a major global health issue that requires immediate attention. Notably, multidrug-resistant (MDR) Pseudomonas aeruginosa, Acinetobacter baumannii, and Enterobacterales (e.g., Klebsiella pneumoniae) are major causes of morbidity and mortality. The World Health Organization (WHO) has identified these pathogens' carbapenem-resistant isolates as the top three priority pathogens for antibiotic…

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Isolation and Characterization of Multidrug Resistance Bacteria from Hospital Sewage Samples, Maharashtra, India

Antibiotics are known as life saver drugs that can act against bacteria. However the increasing problem of antibiotic resistance (ABR) has raised an alarm and has even attracted the attention of the World Health Organization (WHO). As per the guidelines from WHO, many countries including India framed the National Action…

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New Antibiotics for Multidrug-Resistant Bacterial Strains: Latest Research Developments and Future Perspectives

Antibiotics are crown to the modern medicine, and they are the weapon against numerous infectious diseases. The exposure of bacteria to ‘non-lethal levels’ of antibiotics is causing antibiotic resistance (ABR) in them. Multidrug resistance (MDR) is the most common type of resistance. The MDR refers to bacteria showing resistance to…

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Synthetic Antibacterial Minerals: Harnessing a Natural Geochemical Reaction to Combat Antibiotic Resistance

The misuse and overuse of antibiotics in livestock and clinical settings is increasing the natural selection of multidrug-resistant bacteria. The resultant is antibiotic resistance bacteria along with the rise in mortality and financial burden on livestock and the healthcare industry. Hence, there is a need for novel strategies to deal…

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Off-Label Use of Antibacterials in a Context of Antimicrobial Resistance Threat

One of the global challenges in the area of  health  is  antimicrobial  resistance,  and  it  is  urgent  to  rethink  the  use  of  antimicrobial  drugs. The use of clinical and epidemiological methods to analyze the potential benefits and risks of drug therapy  has now become  a  requirement  for  the  rational use…

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Eco-friendly Ways to Feed Pigs without Antibiotics

The health of the young piglet depends on the body’s resistance and immune status which is largely determined by the diet of the animal. If the diet is not taken properly, the pigs become very sensitive to the diseases caused by pathogens. Until recently, the most common way to fight…

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Contamination of Fresh Produce with Antibiotic-Resistant Bacteria and Associated Risks to Human Health: A Scoping Review

Daily intake of fruits and vegetables is necessary to fulfil the daily requirements of vitamins and minerals for human body. But, consuming them raw exposes us to many bacteria including the resistant ones. Different genera of drug resistant bacteria were identified from raw vegetables and fruits, the most common being…

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Emergence of Methicillin Resistance Predates the Clinical Use of Antibiotics

Antibiotic resistance is an ancient phenomenon common in environmental bacteria, however resistance in human pathogen is the unpredicted modern phenomenon which is a result of overuse and misuse of antibiotics. One of the most common antibiotic resistant bacteria is Methicillin-resistant S. aureus. It is the major cause of over 1,71,000…

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Effect on Antimicrobial Resistance of a Policy Restricting Over-the-Counter Antimicrobial Sales in a Large Metropolitan Area, São Paulo, Brazil

It is a well-established fact that misuse of antibiotics is the prime factor accelerating the emergence and spread of antibiotic resistance. To counteract this, the World Health Organisation recommends restricting Over the Counter (OTC) antibiotic sales globally. Many policies are in place for regulating OTC sales, especially in low- and…

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The Usage of Antibiotics by COVID-19 Patients with Comorbidities: The Risk of Increased Antimicrobial Resistance

The use of antibiotics in healthcare settings is very common and it is more critical in a conditions like intensive care unit or in case of immunocompromised patients. The physicians need to prescribe the antibiotics sometimes to treat the primary bacterial infection/s or at times to avoid any secondary condition.…

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