Short Review on the Potential Alternatives to Antibiotics in the Era of Antibiotic Resistance

Antibiotics were once considered wonder drugs. They worked fantastically to treat infections and bring down the mortality and morbidity due to bacterial infections. Unfortunately, humans misused these drugs resulting in antibiotic resistance. As a result, antibiotics started to fail. Pharmaceutical companies are showing more interest in funding drugs like anticancer…

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A Synthetic Lipopeptide Targeting Top-Priority Multidrug-Resistant Gram-Negative Pathogens

Antimicrobial resistance is a major global health issue that requires immediate attention. Notably, multidrug-resistant (MDR) Pseudomonas aeruginosa, Acinetobacter baumannii, and Enterobacterales (e.g., Klebsiella pneumoniae) are major causes of morbidity and mortality. The World Health Organization (WHO) has identified these pathogens' carbapenem-resistant isolates as the top three priority pathogens for antibiotic…

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Enhancing Pharmacists’ Role in Developing Countries to Overcome the Challenge of Antimicrobial Resistance: A Narrative Review

Antimicrobial resistance (AMR) is a global health challenge and developing countries are more vulnerable to the adverse health impacts of AMR. Health care workers including pharmacists can play a key role to support the appropriate use of antimicrobials in developing countries and reduce AMR. Success stories of pharmacist-led programs in…

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Analysis of Viromes and Microbiomes from Pig Fecal Samples Reveals that Phages and Prophages Rarely Carry Antibiotic Resistance Genes
This photo taken on August 10, 2018 shows a pig standing in a pen at a pig farm in Yiyang county, in China's central Henan province. - The powdery yellow mixture of soybean-based feed for pigs -- one-fifth soy -- has become pricier as the trade spat between China and the US escalates, with Beijing slamming US soybean imports with tariffs of 25 percent last month. (Photo by GREG BAKER / AFP) / TO GO WITH China-US-trade-pork, FOCUS by Becky DAVIS (Photo credit should read GREG BAKER/AFP/Getty Images)

Analysis of Viromes and Microbiomes from Pig Fecal Samples Reveals that Phages and Prophages Rarely Carry Antibiotic Resistance Genes

The transfer of antibiotic resistance genes (ARGs) has become a crucial health concern and understanding the process of transmission is important for human health. With the help of sequencing techniques, it is now possible to examine the contribution of mobile genetic elements towards the spread of ARGs. The spread of…

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Understanding the Complexities of Antibiotic Prescribing Behaviour in Acute Hospitals: A Systematic Review and Meta-Ethnography

The injudicious use of antibiotics stands as the number one reason for the development and spread of antibiotic resistance in humans. This is further intensified due to the human behaviours which are intensely intertwined with antibiotic use and practices. Inappropriate prescription of antibiotics by the healthcare professional is an issue.…

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Current Challenges and Future Opportunities of Phage Therapy

The discovery and introduction of antibiotics in clinical practice had revolutionized the field of modern medicine. However, the golden period of antibiotics has come to an end due to the injudicious use of antibiotics, the bacteria managed to develop multiple antibiotic resistance (ABR) mechanisms. ABR is a major public health…

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Time for a renewed focus on the role of cleaners in achieving safe health care in low and middle-income countries

Water, sanitation and hygiene (WASH) is an enabling factor to infection prevention and control (IPC). Both of these, WASH and IPC, contribute to preventing antimicrobial resistance (AMR) transmission and contributing to safe and quality healthcare. Access to safe water in hospitals can support the delivery of clean care. WASH enables…

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